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ANTITUMOR MEDICINAL COMPOSITION DERIVED FROM THUJOPSIS DOLABRATA AND INHALATION FORMULATION THEREOF NEW_EN meetings

Foreign code F190009973
File No. (H29-S13)
Posted date Oct 28, 2019
Country WIPO
International application number 2019JP006713
International publication number WO 2019167823
Date of international filing Feb 22, 2019
Date of international publication Sep 6, 2019
Priority data
  • P2018-036853 (Mar 1, 2018) JP
Title ANTITUMOR MEDICINAL COMPOSITION DERIVED FROM THUJOPSIS DOLABRATA AND INHALATION FORMULATION THEREOF NEW_EN meetings
Abstract [Problem] To provide a medicinal composition derived from a natural plant that has an excellent antitumor effect with little side effect and an inhalation formulation of the same.
[Solution] A medicinal composition characterized by comprising an essential oil derived from Thujopsis dolabrata, which is a coniferous tree belonging to Thujopsis of Cupressaceae, or a volatile component of the essential oil.
Outline of related art and contending technology BACKGROUND ART
Cypress family belonging to the genus dolabrata oak: Japanese cypress leaves are, in the japanese name dolabrata, in the name of the Thujopsis dolabrata. Oak is, unique softwood and Japan, and oak Aomori present within the prefecture Aomori, Ishikawa Prefecture noto oak is noto peninsula widely distributed is widely known.
Oak the essential extracted from oak, and is of normal, low toxicity of normal, chlamydia, MRSA, candida has antimicrobial activity against, has the effect of the preservative have been reported (Non-Patent Document 1-3). Utilizing this characteristic, are combined with the artificially dentifrice is of normal, cosmetics, hair care composition, food preservatives and the like are used. Oak the essential, other components of normal, for example β-Dolabrin, γ -Thujaplicin,4-Acetyltroplone and the like, the effect of suppressing stress (non-patent document 4) or via IgA (non-patent document 5) action immunopotentiating and the like have been reported.
Included in the anti-tumor effect of oak the essential as of normal, non-patent document 6 to the anti-tumor effect with respect to the prostate cancer cells, lung cancer cells on the non-patent document 7 with respect to the effect of inducing cell death has been disclosed. The present inventors has, other than the volatile components of the oak the essential of normal focusing is also included, as compared to the synergistic effect thereof for gastric cancer cells (non-patent document 8). The present inventors, as a result of study in further detail, and achieved the present invention.
Scope of claims (In Japanese)[請求項1]
 ヒノキ科アスナロ属の針葉樹であるヒバ(Thujopsis dolabrata)由来の精油又は当該精油の揮発性成分を含有する抗腫瘍医薬組成物。

[請求項2]
 ヒノキ科アスナロ属の針葉樹であるヒバ(Thujopsis dolabrata)由来の精油の揮発性成分からなる、癌の治療又は予防のために使用する吸引投与剤。

[請求項3]
 前記吸引投与する方法は室内の生活空間に前記ヒバ由来の精油又はその揮発性成分を噴霧するものである請求項2記載の吸引投与剤。

[請求項4]
 前記吸引投与する方法は前記ヒバ由来の精油が含まれたヒバ精油揮発性成分の発生材をマスクに保持させることを特徴とする請求項2記載の吸引投与剤。

[請求項5]
 前記ヒバ由来の精油の揮発性成分にはツヨプセンが含まれていることを特徴とする請求項2記載の吸引投与剤。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA
  • Inventor
  • NAGATA Takuya
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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