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TRANSFORMANT, AND METHOD USING SAID TRANSFORMANT TO DETECT PRESENCE OR ABSENCE OF REDUCED PHOSPHOROUS COMPOUND NEW

外国特許コード F190009986
整理番号 (S2018-0428-N0)
掲載日 2019年10月28日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP008137
国際公開番号 WO 2019168163
国際出願日 平成31年3月1日(2019.3.1)
国際公開日 令和元年9月6日(2019.9.6)
優先権データ
  • 特願2018-038036 (2018.3.2) JP
発明の名称 (英語) TRANSFORMANT, AND METHOD USING SAID TRANSFORMANT TO DETECT PRESENCE OR ABSENCE OF REDUCED PHOSPHOROUS COMPOUND NEW
発明の概要(英語) An objective of the present invention is to provided transformants of various species that depend on phosphorous acid for growth, and a method using said transformants to detect the presence or absence of reduced phosphorous compounds. The present invention uses a transformant in which the function of genes that code phosphoric acid transporter proteins and phosphoric acid ester transporter proteins is missing, and into which a gene that codes hypophosphite transporter proteins has been introduced, the signal peptides of the hypophosphite binding proteins being replaced with signal peptides of the host or a species closely related to the host.
従来技術、競合技術の概要(英語) BACKGROUND ART
In recent years, the use of a wide variety of such transgenic organism can be applied to the fabricated thereon. Genetically engineered organism is made, for example, oral vaccine, or, for the purpose of improvement of the environment is expected to be used.
On the other hand, in order to actually use the genetically engineered biological, some condition. As one of conditions 1, only in a limited location and growth, the growth in biological genetic recombination cannot be other than the location (in other words, the high confinement effects genetically engineered biological) needs to be made. If such a transgenic organism, the naturally occurring biological genetic recombination even if the leakage, the transgenic organism cannot be grown in a naturally occurring, genetically engineered biological nature by the contamination can be prevented.
In this way for making such transgenic organism has been developed a variety of methods. One of the methods 1, to an organism, a compound that does not exist in the natural world a method of providing nutritional auxotrophy (auxotrophic (synthetic auxotrophy) ) is synthesized. As a concrete example of the manufacturing method disclosed in, Non-Patent Document 1 can be exemplified. In non-patent document 1, inventors of the present invention, the environment in which there is little dependent on the phosphorous acid so that the metabolic altering the growth, the effect of the world highest level of containment, transfected with successful fabrication.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • HIROSHIMA UNIVERSITY
  • 発明者(英語)
  • HIROTA, Ryuichi
  • KURODA, Akio
  • MOTOMURA, Kei
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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