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MEDICINAL COMPOSITION NEW

外国特許コード F190009988
整理番号 (S2018-0494-N0)
掲載日 2019年10月28日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP012429
国際公開番号 WO 2019188950
国際出願日 平成31年3月25日(2019.3.25)
国際公開日 令和元年10月3日(2019.10.3)
優先権データ
  • 特願2018-058171 (2018.3.26) JP
発明の名称 (英語) MEDICINAL COMPOSITION NEW
発明の概要(英語) A medicinal composition for treating a central neurodegenerative disease, said medicinal composition comprising at least one member selected from the group consisting of nicotine, nobiletin, sinensetin and Nchinpi, characterized in that the central neurodegenerative disease is associated with mitochondrial dysfunction.
従来技術、競合技術の概要(英語) BACKGROUND ART
Mitochondrial ATP stable supply of the maintenance functions of the system, to be essential for cell viability. Therefore, many eukaryotic ATP in a cell of the stable supply system failure, i.e. failure of mitochondrial function can be a definitive cause cell death. For example, 2 known as a large central neurodegenerative disease is Alzheimer's disease and Parkinson's disease (AD) (PD) is, the onset of cell death of neuronal cells cause an known.
In this case, neurons or nerve axons and dendrites of the morphological structure and the like in order to maintain the indispensable and the actin cytoskeleton, actin depolymerization-ATP consumption polymerization cycle, the total energy consumption of up to 1-50% of the brain are estimated (non-patent document 1, 2). Therefore, in the nerve cells in the brain, brain ATP balance does not fail in such a stable supply of the ATP system may be built.
On the other hand, V-1 (also called Myotrophin.) Is a protein, and protein , V-1 is human, 118 amino acids. V-1 is, in the molecule through the ankyrin binding protein actin capping protein (CP, CapZ). The CP, and coupled to the end of the actin filament, where the polymerization of actin by blocking the suppressed. V-1 is, the actin capping activity, thereby, promoting the formation of the actin cytoskeleton has been known (Non-Patent Document 3).
However, V-1 mitochondria function, is not known.
Shinensechin, nobiletin is, as can be included in the skin of tough genus (Citrus) and poly methoxy flavonoid, citrus unshiu peel (nobilis) is, in the mature of the mandarin orange satsuma mandarin or pericarp. Nobiletin shinensechin and is, has an effect of an anti-dementia has been known. Also, the citrus unshiu peel, herbal a longer used. However, any of the functions of the mitochondria, has not been known. Nicotine, mainly leaf tobacco alkaloids Nicotiana tabacum a kind of included. Smoking risk of Parkinson's disease that is known to reduce the systematic reviews (non-patent document 4). However, the nicotine mitochondria function, is not known.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOHOKU UNIVERSITY
  • 発明者(英語)
  • YAMAKUNI, Tohru
  • KAWAHATA, Ichiro
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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