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METHOD FOR PRODUCING CARP-DERIVED ANTIBACTERIAL AGENT AND ANTIBACTERIAL TREATMENT APPARATUS meetings

Patent code P100000200
Posted date Jun 5, 2009
Application number P2009-095745
Publication number P2010-248075A
Patent number P5598810
Date of filing Apr 10, 2009
Date of publication of application Nov 4, 2010
Date of registration Aug 22, 2014
Inventor
  • (In Japanese)青木 恭彦
Applicant
  • (In Japanese)国立大学法人三重大学
Title METHOD FOR PRODUCING CARP-DERIVED ANTIBACTERIAL AGENT AND ANTIBACTERIAL TREATMENT APPARATUS meetings
Abstract PROBLEM TO BE SOLVED: To provide a method for obtaining a large amount of an antibacterial agent from the blood of carp, an antibacterial treatment apparatus using the antibacterial agent, and the like.
SOLUTION: The antibacterial agent can be produced by isolating erythrocytes from the blood of carp, purifying a membrane fraction from these erythrocytes, thereafter adding a lithium salt to the membrane fraction to be solubilized, and fractionating free glycophorin in the presence of a surfactant with the use of anion-exchange chromatography. The antibacterial treatment apparatus has a carrier on which this antibacterial agent is immobilized and an outer cylinder including this carrier and this outer cylinder is provided with an inlet for introducing water before treatment to bring the water into contact with the carrier and an outlet for allowing the water after treatment to flow out.
Outline of related art and contending technology (In Japanese)



ヒトグリコホリンは、病原性ウィルスの受容体、レクチンへの接着能など生体防御機能や血液型決定基などの種々の生理活性を有していると云われている。本発明者は、魚類赤血球膜にもグリコホリン様の物質が存在すれば、ヒトグリコホリンと同様の生理機能を持つ可能性があり、魚病の防止や抗生物質に頼らない新規な薬物の開発にもつながるのではないかと考え、コイ血液から数個の糖類からなる抗菌剤を得ることに成功した(特許文献1)。

Field of industrial application (In Japanese)



本発明は、コイ由来抗菌剤の製造方法及び、その抗菌剤を用いた抗菌処理装置に関する。

Scope of claims (In Japanese)
【請求項1】
 
コイ血液から赤血球を単離し、この赤血球から膜画分を精製した後に、前記膜画分にリチウム塩を加えて可溶化し、過剰なリチウム塩を除去した後、遊離したグリコホリンをコール酸ナトリウムの存在下で、陰イオン交換クロマトグラフィーを用いて分画することを特徴とする抗菌剤の製造方法。
IPC(International Patent Classification)
F-term
Drawing

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JP2009095745thum.jpg
State of application right Registered
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