|発明の名称||METHOD FOR MEASURING THROMBIN INACTIVATION KINETICS FOR ABNORMAL THROMBIN ACTING AS COAGULATION FACTOR, METHOD OF TESTING AND POLYNUCLEOTIDE|
PROBLEM TO BE SOLVED: To provide a method of measurement for a new onset case of venous thrombosis, in which gene mutation becoming a risk of the venous thrombosis as reported so far can not be found, and a new method for testing the easiness of becoming the thrombosis for a subject.
SOLUTION: This method of measurement is provided by adding a prothrombin activator to a sample at least containing components originated from the plasma of the subject to convert the prothrombin to thrombin, and then adding a coagulation inhibitory factor inactivating normal thrombin to the sample and comparing the residual thrombin activity of the sample after a prescribed reaction time with normal values. Also, the easiness of becoming the thrombosis for the subject is tested by determining the kind of base at 1787th of the base sequence of a cDNA corresponding to the prothrombin gene originated from the subject on taking the adenine of a translation-starting codon of the cDNA as a first base, and comparing with standards in that when that base is thymine, the subject tends to become thrombosis and when it is guanine, the subject hardly becomes thrombosis.
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