|発明の名称||LIFE-SHORTENED MODEL NON-HUMAN MAMMAL|
PROBLEM TO BE SOLVED: To provide a model non-human animal that is useful for development of agent such as a chronic kidney disease therapeutic agent and is more superior than before as a model of a chronic kidney disease.
SOLUTION: A life-shortened model non-human mammal is provided which is characterized by the function of the Agtrap gene being inhibited. In the non-human animal suffering a loss of ATRAP, the exacerbation of renal fibrosis (namely, chronic kidney disease, a state of a disease of terminal renal insufficiency) is observed, and the life is significantly shortened while abnormal conditions of other appearance are not present. Various retrogradation model mice conventionally known exhibit a wide variety of retrogradation traits in a whole body and have a clearly abnormal appearance. In the ATRAP deficit mouse, the abnormal conditions of the appearance are not present unlike these well-known retrogradation model mice, and the retrogradation trait itself is equal to wild type mice of the comparison. A model of the present invention is expected to greatly contribute even to the development of a therapeutic agent of the severe renal disease (chronic kidney disease containing terminal renal insufficiency) being irreversible and highly important.
- 公立大学法人横浜市立大学 研究推進センター
- URL: http://www.yokohama-cu.ac.jp/
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