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単一分子・原子レベルの反応制御 超天然物の反応制御と分子設計

研究報告コード R990004270
掲載日 2001年2月6日
  • 平間 正博
  • 東北大学大学院理学研究科
  • 東北大学大学院理学研究科
報告名称 単一分子・原子レベルの反応制御 超天然物の反応制御と分子設計
報告概要 本研究は有機合成化学を機軸に,物理有機化学,コンピュータと,分子生物学,構造生物学を併せて,蛋白質複合体に焦点を置き,その三次元構造と機能発現の反応原理を解明する。
  • 有機化学反応一般
  • 蛋白質・ペプチド一般
  • 抗腫よう薬の基礎研究
  • 抗生物質の合成
  • 抗腫よう抗生物質の基礎研究
関連発表論文 (1)T. Kaneko, T. Takahashi, and M. Hirama, Synthetic Study of Neocarzinostatin Chromophore: Stereoselective Synthesis of N-Methylfucosamine and Its a-Glycoside. Heterocycles, 47, 91-96 (1998).
(2)T. Noda, A. Ishiwata, S. Uemura, S. Sakamoto, and M. Hirama, Synthetic Study of Pinnatoxin A: Stereoselective Synthesis of the BCD-ring Unit, a Novel 6,5,6-Bis-spiroketal System. SYNLETT, 298-300 (1998).
(3)T. Oishi, Y. Nagumo, and M. Hirama, Convergent Synthesis of the trans-Fused 6-n-6-6 (n-7-10) Tetracycric Ether System Based on a Ring-closing Metathesis Reaction. Chem. Commun., 1041-1042 (1998)
(4)M. Yamaguchi, M. Arisawa, and M. Hirama, Ortho-Vinylation Reaction of Anilines. Chem. Commun., 1399-1400 (1998).
(5)T. Mita, S. Kawata, and M. Hirama, Evidence for Spontaneous Cycloaromatization of Nine-Membered Monocyclic Enediyne. Chemistry Lett., 959-960 (1998).
(6)S. Kawata and M. Hirama, Synthetic Study of the Kedarcidin Chromophore: Efficient Construction of the Aryl Alkyl Ether Linkage. Tetrahedron Lett., 39, 8707-8710 (1998).
(7)M. Yamaguchi, M. Arisawa, K. Omata, K. Kabuto, M. Hirama, and T. Uchimaru Ortho-Vinylation Raection of Phenols with Ethyne. J. Org. Chem., 63, 7298-7305 (1998).
(8)I. Sato, K. Toyama, T. Kikuchi, and M. Hirama, New Synhetic Route to the Highly Strained Cores of C-1027 and Neocarzinostatin Chromophores. Synlett, 1308-1310 (1998).
(9)K. Takahashi, M. Hagiwara, S. Ashizawa, and M. Hirama, Concise Synthesis of the Naphthoate Component of N1999-A2. Synlett, 71-72 (1999).
(10)T. Kaneko, M. Takahashi, and M. Hirama, Photochemical Cycloaromatization of Nonbenzenoid Endiynes. Angew. Chem. Internat. Ed. Engl., 38, 1267-1268 (1999).
(11)T. Kaneko, M. Takahashi, and M. Hirama, Benzannelation Alters the Rate Limiting Step in Enediyne Cycloaromatization. Tetrahedron Lett., 40, 2015-2018 (1999).
(12)G. Hirai, H. Oguri, and M. Hirama, Synthetic Study of Zoanthamine Alkaloids: The C-ring Model Possessing Three Consecutive Quaternary Carbons. Chemistry Lett., 141-142 (1999).
(13)K. Kano, H. Kamo, S. Negi, T. Kitae, R. Takaoka, M. Yamaguchi, H. Okubo, and M. Hirama, Chiral Recognition of an Anionic Tetrahelicene by Native Cyclodextrins. Enantioselectivity Dominated by Location of a Hydrophilic Group of the Guest in a Cyclodextrin Cavity. J. Chem. Soc., Perkin Trans. 2, 15-21 (1999).
(14)A. Ishiwata, S. Sakamoto, T. Noda, and M. Hirama, Synthetic Study of Pinnatoxin A: Intramolecular Diels-Alder Approach to the AG-ring. Synlett, 692-694 (1999).
(15)A. Nitta, T. Noda, and M. Hirama, Synthetic Study of Pinnatoxin A: Intramolecular Alkylation Approach to the G-ring. Synlett, 695-696 (1999).
(16)I. Sato, T. Kikuchi, and M. Hirama, Synthetic Study of C-1027 Chromophore: Enantioselective Synthesis of β-Tyrosine Moiety and Effective Aryl Ether Formation. Chemistry Lett., 511-512 (1999).
(17)T. Oishi, M. Maruyama, M. Shoji, K. Maeda, N. Kumahara, S. Tanaka, and M. Hirama, Enantioselective Synthesis of the Medium Ring Ethers, Tetrahydrooxepin, Oxocane and Hexahydrooxonin, of Ciguatoxin. Extensive Ring-Expansion and Chemoenzymatic Desymmetrization Strategy. Tetrahedron, 55, 7471-7498 (1999).
(18)K. Maeda, T. Oishi, H. Oguri, and M. Hirama, Convergent Synthesis of the ABCDE Ring Framework of Ciguatoxin. Chem. Commun., 1063-1064 (1999).
(19)M.J. Lear and M. Hirama, Convenient Route to Derivatives of the 2-Deoxysugar Submits of the Kedarcidin Chromophore: L-Mycarose and L-Kedarosamine. Tetrahedron Lett., 40, 4897-4900 (1999)
  • 戦略的基礎研究推進事業、研究領域「単一分子・原子レベルの反応制御」研究代表者 平間 正博(東北大学大学院理学研究科)/科学技術振興事業団
  • 平間 正博. 単一分子・原子レベルの反応制御 超天然物の反応制御と分子設計. 戦略的基礎研究推進事業 平成10年度 研究年報,1999. p.374 - 376.