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(In Japanese)発生・分化を規定する新規シグナル伝達ネットワーク

Research report code R000000119
Posted date Sep 30, 2002
  • (In Japanese)松本 邦弘
  • (In Japanese)名古屋大学大学院理学研究科
Research organization
  • (In Japanese)名古屋大学大学院理学研究科
Report name (In Japanese)発生・分化を規定する新規シグナル伝達ネットワーク
Technology summary (In Japanese)TGF-βスーパーファミリー,TollファミリーやWntファミリーは,高等真核生物の発生及び分化を規定する細胞外リガンドとして不可欠の役割を果たしている。TGF-βスーパーファミリーのシグナル伝達を制御するMAPキナーゼキナーゼキナーゼとして分離したTAK1(TGF-β-activated kinase)が,Tollファミリーに属するIL-1シグナル伝達経路に関与することを明らかにした。さらに,線虫のTAK1ホモログTLK-1(TAK1-Like Kinase)が,Wntシグナル伝達経路による内胚葉誘導を正に制御していることが明らかとなった。これらの成果を基に
Research field
  • Cell physiology in general
  • Cell division and proliferation
  • Function of cell components
  • Animal biochemistry
Published papers related (In Japanese)(1)Takaesu, G., Kishida, S., Hiyama, A., Yamaguchi, K., Shibuya, S., Irie, I., Ninomiya-Tsuji, J. and Matsumoto, K. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell, 5: 649-658 (2000).
(2)Takatsu, Y., Nakamura, M., Stapleton, M., Danos, M.C., Matsumoto, K., O'Connor, M.B., Shibuya, H. and Ueno, N. TAK1 participates in JNK signaling during Drosophila development. Mol. Cell. Biol., 20: 3015-3026 (2000).
(3)Kishimoto, K., Matsumoto, K. and Ninomiya-Tsuji, J. TAK1 MAP kinase kinase kinase is activated by autophosphorylation within its activation loop. J. Biol. Chem., 275: 7359-7364 (2000).
(4)Ninomiya-Tsuji, J., Kishimoto, K., Hiyama, A., Inoue, J., Cao, Z. and Matsumoto, K. The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature, 398: 252-256 (1999).
(5)Menegini, M.D., Ishitani, T., Carter, C., Hisamoto, N., Ninomiya-Tsuji, J., Thorpe, J., Matsumoto, K. and Bowerman, B. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis. elegans. Nature, 399: 793-797 (1999).
(6)Ishitani, T., Ninomiya-Tsuji, J., Nagai, S., Nishita, M., Menegini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H. and Matsumoto, K. The TAK1-NLK-MAPK related pathway antagonizes signalling between β-catenin and the transcription factor TCF. Nature, 399: 798-802 (1999).
(7)Adachi-Yamada, T., Fujimura-Kamada, K., Nishida, Y. and Matsumoto, K. Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing. Nature, 400: 166-169 (1999).
(8)Suzanne, M., Irie, K., Glise, B., Agnes, F., Mori, E., Matsumoto, K. and Noselli, S. The Drosophila p38 MAPK pathway is required during oogenesis for asymmetric development. Genes & Dev., 13: 1464-1474 (1999)
(9)Yamaguchi, K., Nagai, S., Ninomiya-Tsuji, J., Nishita, M., Tamai, K., Irie, K., Ueno, N., Nishida, E., Shibuya, H. and Matsumoto, K. XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J., 18: 179-187 (1999).
(10)Kawasaki M., Hisamoto N., Iino Y., Yamamoto M., Ninomiya-Tsuji J. and Matsumoto, K. A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. EMBO J., 18: 3604-3615 (1999).
(11)Kondo, T., Matsumoto, K. and Sugimoto, K. Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway. Mol. Cell. Biol., 19: 1136-1143 (1999).
(12)Adachi-Yamada, T., Nakamura, M., Irie, K., Tomoyasu, Y., Sano, Y., Mori, E., Goto, S., Ueno, N., Nishida, Y. and Matsumoto, K. p38 mitogen-Activated Protein Kinase can be Involved in transforming growth factor β superfamily signal transduction in Drosophila wing morphogenesis. Mol. Cell. Biol., 19: 2322-2329 (1999).
(13)Inagaki, M., Schmelzle, T., Yamaguchi, K., Irie, K., Hall, M.N. and Matsumoto, K. PDK1 homologs activate the Pkc1-MAP kinase pathway in yeast. Mol. Cell. Biol., 19: 8344-8352 (1999).
(14)Nakashima, S., Wang, S., Hisamoto, N., Sakai, H., Andoh, M., Matsumoto, K. and Nozawa, Y. Molecular cloning and expression of a stress-responsive mitogen-activated protein kinase-related kinase from Tetrahymena cell. J. Biol. Chem., 274: 9976-9983 (1999).
(15)Hanafusa, H., Ninomiya-Tsuji, J., Masuyama, N., Nishita, M., Fujisawa, J., Shibuya, Y., Matsumoto, K. and Nishida, E. Involvement of the p38 MAP kinase pathway in TGF-β-induced gene expression. J. Biol. Chem., 274: 27161-27167 (1999).
(16)Moriguchi, T., Kawachi, K., Kamakura, S., Masuyama, N., Yamanaka, H., Matsumoto, K., Kikuchi, A. and Nishida, E. Distinct domains of mouse dishevelled are responsible for the JNK/SAPK activation and the axis formation in vertebrates. J. Biol. Chem., 274: 30957-30962 (1999).
Research project
  • Core Research for Evolutional Science and Technology;Genetic Programming
Information research report
  • (In Japanese)松本 邦弘. 生命活動のプログラム 発生・分化を規定する新規シグナル伝達ネットワーク. 戦略的基礎研究推進事業 平成11年度 研究年報.科学技術振興事業団, 2000. p.58 - 62.