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(In Japanese)環境発がん物質の低濃度発がんリスクの解明

Research report code R000000146
Posted date Sep 30, 2002
  • (In Japanese)福島 昭治
  • (In Japanese)大阪市立大学医学部
Research organization
  • (In Japanese)大阪市立大学医学部
Report name (In Japanese)環境発がん物質の低濃度発がんリスクの解明
Technology summary (In Japanese)ラット発がんにおいて,遺伝毒性ならびに非遺伝毒性発がん物質の低用量発がん性には実際上,無作用量があることをweights of evidenceの観点から実証した。さらに発がん中期検索法としての遺伝子改変動物やSCIDマウスの有用性とマーカーの検討,がん関連遺伝子の変異の高感度検出法の開発,および発がん物質の低用量複合作用などについて検討した。研究内容としては,
Research field
  • Molecular genetics in general
  • Influence on animals
  • Carcinogenic mechanisms and factors
  • Diagnosis of tumors (=neoplasms)
  • Toxicity of animal derived substances
Published papers related (In Japanese)(1)Romanenko, A., Lee, C.C.R., Yamamoto, S., Hori, T., Wanibuchi, H., Zaparin, W., Vinnichenko, W., Vozianov, A., Fukushima, S. Urinary bladder lesions after the chernobyl accident: immunohistochemical assessment of p53, proliferating cell nuclear antigen, cyclin D1 and p21WAF1/Cip1. Jpn.J. Cancer Res., 90, 144-153, 1999.
(2)Chen, T., Na, Y., Wanibuchi, H., Yamamoto, S., Lee, C.C.R., Fukushima, S. Loss of heterozygosity in (Lewis×F344)F1 rat urinary bladder tumors induced with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by dimethylarsinic acid or sodium L-ascorbate. Jpn. J. Cancer Res., 90, 818-823, 1999.
(3)Fukushima, S. Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline:relevance to risk assessment. Cancer Lett., 143, 157-159, 1999.
(4)Salim, E.I., Wanibuchi, H., Yamamoto, S., Morimura, K., Mori, S., Makino, S., Nomura, T., Fukushima, S. Low-dose-dependent carcinogenic potential of 2-amino-3-methylimidazo[4,5-f]quinoline in the immunodeficient (SCID) mouse colon. Nutrition and Cancer, 34, 220-228, 1999.
(5)Chen, T., Wanibuchi, H., Wei, M., Morimura, K., Yamamoto, S., Hayashi, S., Fukushima, S. Concentration dependent promoting effects of sodium L-ascorbate with the same total dose in a rat two-stage urinary bladder carcinogenesis. Cancer Lett., 146, 67-71, 1999.
(6)Sukata, T., Ozaki, K., Uwagawa, S., Seki, T., Wanibuchi, H., Yamamoto, S., Okuno, Y., Fukushima, S. Organ-specific, carcinogen-induced increases in cell proliferation in p53-deficient Mice. Cancer Res., 60, 74-79, 2000.
(7)Yamamoto, S., Tada, M., Lee, C.C.R., Masuda, C., Wanibuchi, H., Yoshimura, R., Wada, S., Yamamoto, K., Kishimoto, T., Fukushima, S. p53 status in multiple human urothelial cancers: assessment for clonality by the yeast p53 functional assay in combination with p53 immunohistochemistry. Jpn. J. Cancer Res., 91, 181-189, 2000.
Research project
  • Core Research for Evolutional Science and Technology;Host Defense Mechanism
Information research report
  • (In Japanese)福島 昭治. 生体防御のメカニズム 環境発がん物質の低濃度発がんリスクの解明. 戦略的基礎研究推進事業 平成11年度 研究年報.科学技術振興事業団, 2000. p.206 - 209.