TOP > 研究報告検索 > 免疫系のフレームワーク決定及び免疫制御の分子機構


研究報告コード R000000152
掲載日 2002年9月30日
  • 笹月 健彦
  • 福井 宣規
  • 山本 健
  • 白澤 専二
  • 橋本 修
  • 九州大学生体防御医学研究所/国立国際医療センター
  • 九州大学生体防御医学研究所
  • 九州大学生体防御医学研究所
  • 国立国際医療センター
  • 九州大学生体防御医学研究所
  • 九州大学生体防御医学研究所
  • 国立国際医療センター
報告名称 免疫系のフレームワーク決定及び免疫制御の分子機構
報告概要 本研究は,
  • 分子構造
  • 遺伝子の構造と化学
  • 生体防御と免疫系研究法
  • 移植免疫
関連発表論文 (1)Gapin L, Fukui Y, Kanellopoulos J, Sano T, Casrouge A, Malier V, Beadoing E, Gautheret D, Claverie JM, Sasazuki T, Kouril sky. P. : Quantitative analysis of the T cell repertoire selected by a single peptide-major histo compatibility complex. J.Exp.Med. 187: 1871-1883, 1998
(2)Fukui Y, Hashimoto O, Inayoshi A, Gyotoku T, Sano T, Koga T, Gushima T, Sasazuki, T. Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor β chain. J.Exp.Med. 188:897-907, 1998.
(3)Gyotoku T, Fukui Y, Sasazuki T. :An endogenously processed self peptide and the corresponding exogenous peptide bound to the same MHC classII molecule could be distinct ligands for TCR with different kinetic stability. Eur.J.Immunol. 28:4050-4061, 1998.
(4)Tana T, Kamikawaji N, Savoie C.J, Sudo T, Kinoshita Y, Sasazuki T.: An HLA-binding-motif aided peptide epitope library : A novel library design for the screening of HLA-DR4-restricted antigenic peptides recognized by CD4+ T cells. J.Human Genet. 43: 14-21, 1998.
(5)Ono T, Zamberedetti,MR, Yamasaki K, Kawano Y, Kamikawaji N, Ito H, Sakurai M, Nishimura Y, Kira J, Kanazawa I, Sasazuki T.: Molecular analysis of HLA class I (HLA-A and -B) and HLA class II (HLA-DRB1) genes in Japanese patients with multiple sclerosis (Western type and Asian type). Tissue Antigens. 52:539-542,1998.
(6)Nishimura H, Washizu J, Naiki Y, Hara T, Fukui Y, Sasazuki T, Yoshikai Y:MHC class II-dependent NK1.1+γ δ T cells are induced in mice by Salmonella infection. J. Immunol., 162:1573-1581, 1999
(7)Sano T, Yamamoto K, Fukui Y, Sasazuki T: Spontaneous clustering of Thy-1 antigens on CD4+ CD8+ thymocytes lacking TCR engagement by MHC/peptide complexes. Eur. J. Immunol 29:403-412, 1999
(8)Savoie CJ, Kamikawaji N, Sasazuki T.: The peptide binding motif of HLA-A*0217. Immunogenetics, 49:567-570, 1999
(9)Kawamura K, Yamamura T, Yokoyama K, Chui DH, Fukui Y, Sasazuki T, Inoko H, David CS, Tabira T.: HLA-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. J. Clin. Invest. 105:977-984, 2000.
(10)Fukui Y, Oono T, Cabaniols JP, Nakao K, Hirokawa K, Inayoshi A, Sanui T, Kanellopoulos J, Iwata E, Noda M, Katsuki M, Kourilsky P, Sasazuki T. Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residne at a T cell receptor contact. Proc. Natl. Acad. Sci. USA 97:13760-13765, 2000.
(11)Wataya M, Sano T, Kamikawaji N, Tana T, Yamamoto K, Sasazuki T. Comparative analysis of HLA restriction and cytokine production in hepatitis B surface antigen-specific T cells from low-and high-antibody responders in vaccinated humans. J. Human Genet. 46:197-206, 2001.
(12)Sakai K, Shirasawa S, Ishikawa N, Ito K, Tamai H, Kuma K, Akamizu T, Tanimura M, Furugaki K, Yamamoto K, Sasazuki, T. Identification of susceptibility loci for autoimmune thyroid disease to 5831-833 and Hashimoto's thyroiditis to 8823-824 by multipoint affected sib-pair linkage analysisi in Japanese. Hum. Mol. Genet. 10:1379-1386, 2001.
(13)Fukui Y, Hashimoto O, Sanui T, Oono T, Koga H, Abe M, Inayoshi A, Noda M, Oike M, Shirai T, Sasazuki T. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyle migration. Nature 412: 826-831, 2001.
(14)Oono T, Fukui Y, Masuko S, Hashimoto O, Ueno T, Sanui T, Inayoshi A, Noda M, Sata M, Sasazuki T. Organ-specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide. J. Clin. Invest. in press 2001.
  • 戦略的基礎研究推進事業、研究領域「生体防御のメカニズム」研究代表者 笹月 健彦(九州大学生体防御医学研究所)/科学技術振興事業団
  • 笹月 健彦. 生体防御のメカニズム 免疫系のフレームワーク決定及び免疫制御の分子機構. 戦略的基礎研究推進事業 平成11年度 研究年報.科学技術振興事業団, 2000. p.237 - 240.