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研究報告コード R000000153
掲載日 2002年9月30日
  • 杉山 雄一
  • 東京大学大学院薬学系研究科
  • 東京大学大学院薬学系研究科
報告名称 異物排除システムの分子基盤
報告概要 平成11年度研究実施計画に基ずき,医薬品を含む広範な低分子異物に対して生体が備えている異物排除機構について,
5)代謝・排泄協関解析グループ(異物解毒における抱合酵素と一次性輸送担体の協関関係の分子的機構をin vitroで再現),である。
  • 生物学的機能
  • 人間に対する影響
  • 細胞膜の輸送
  • 生物薬剤学(基礎)
関連発表論文 (1)I.Kino, Y.Kato, J.H.Lin and Y. Sugiyama: Renal handling of biphosphonate alendronate in rats. Biopharm. Drug Dispos., 20: 193-198 (1999)
(2)H. Ishizuka, K. Konno, T. Shiina, H. Naganuma, N. Nishimura, K.Ito, H.Suzuki and Y.Sugiyama: Species differences in the transport activity for organic anions across the bile canalicular membrane. J.Pharmacol.Exp.Ther., 290:1324-1330 (1999)
(3)S.Akhteruzzaman, Y.Kato, H.Kouzuki, H.Suzuki, A.Hisaka, B.Stieger, P.J.Meier and Y.Sugiyama: Carrier-mediated hepatic uptake of peptidic endothelin antagonists in rats. J.Pharmacol.Exp.Ther., 290: 1107-1115 (1999)
(4)H. Sasabe, Y. Kato, A. Tsuji, and Y. Sugiyama: Differences in the hepatobiliary transport of two quinolone antibiotics, grepafloxacin and lomefloxacin, in the rat. Biopharm. Drug Disp., 20: 151-158 (1999)
(5)K. Niinuma, Y. Kato, H. Suzuki, C.A. Tyson, V. Weizer, J.E. Dabbs, R. Froelich, C. E. Green, and Y. Sugiyama: Primary active transport of organic anions on bile canalicular membrane in humans. Am. J. Physiol., 276: G1153-G1164 (1999)
(6)Y. Han, Y. Kato, H. Kusuhara, H. Suzuki, M. Shimoda, E. Kokue, and Y. Sugiyama: Kinetic profile of overall elimination of 5-methyltetrahydropteroylglutamate in rats. Am. J. Physiol., 276: E580-E587 (1999)
(7)Y. Kato, S. Akhteruzzaman, A. Hisaka, and Y. Sugiyama: Hepatobiliary transport governs overall elimination of peptidic endothelin antagonists in rats. J. Pharmacol. Exp. Ther., 288: 568-574 (1999)
(8)X. Chu, Y. Kato, and Y. Sugiyama: Possible involvement of P-glycoprotein in biliary excretion of CPT-11 in rats. Drug Metab. Disp., 27: 440-441 (1999)
(9)S. Akhteruzzaman, Y. Kato, A. Hisaka, and Y. Sugiyama: Primary active transport of peptidic endothelin antagonists by rat hepatic canalicular membrane. J. Pharmacol. Exp. Ther., 288: 575-581 (1999)
(10)H.Kouzuki, H.Suzuki, R.Ohashi, K.Ito and Y.Sugiyama: Contribution of organic anion transporting polypeptide to the uptake of its possible substrates into rat hepatocytes. J. Pharmacol. Exp.Ther., 288:627-634 (1999)
(11)X.-Y.Chu, H.Suzuki, K.Ueda, Y.Kato, S.Akiyama and Y.Sugiyama: Active efflux of CPT-11 and its metabolites in human KB-derived cell lines. J. Pharmacol. Exp. Ther., 288, 735-741 (1999)
(12)M.Honma, H.Suzuki, H.Kusuhara, M.Naito, T.Tsuruo and Y. Sugiyama: High affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line(MBEC4). J.Pharmacol.Exp.Ther., 288: 198-203 (1999)
(13)S.-H.Song, H.Suzuki, R. Kawai and Sugiyama, Y.: Effect of PSC 833, a P-gp modulator, on the disposition of vincristine and digoxin in rats. Drug Metab.Dispos., 27: 689-694 (1999)
(14)M.Achira, H.Suzuki, K.Ito and Y.Sugiyama: Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P450 3A4. Pharm. Sci. 1(1999)
(15)Y.Gotoh, H.Suzuki, S.Kinoshita, T.Hirohashi, Y.Kato and Y.Sugiyama: Involvement of an organic anion transporter(cMOAT/MRP2) in gastrointestinal secretion of glutathione conjugates in rats. J.Pharmacol. Exp. Ther., 292:433-439 (2000)
(16)H.Kouzuki, H.Suzuki1, B.Stieger, P.J.Meier and Y.Sugiyama: Characterizatiion of the transport properties of organic anion transporting polypeptide1 (oatp1) and Na+/taurocholate co-transporting polypeptide(Ntcp): comparative studies on the inhibitory effect of their possible substrates in hepatoyctes and cDNA-transfected COS-7 cells. J.Pharmacol.Exp.Ther., 292: 505-511 (2000)
  • 戦略的基礎研究推進事業、研究領域「生体防御のメカニズム」研究代表者 杉山 雄一(東京大学大学院薬学系研究科)/科学技術振興事業団
  • 杉山 雄一. 生体防御のメカニズム 異物排除システムの分子基盤. 戦略的基礎研究推進事業 平成11年度 研究年報.科学技術振興事業団, 2000. p.241 - 247.