Top > Search Research paper > (In Japanese)複合体形成に基づく膜タンパク質の機能制御

(In Japanese)複合体形成に基づく膜タンパク質の機能制御

Research report code R000000231
Posted date Sep 30, 2002
  • (In Japanese)橘 和夫
  • (In Japanese)東京大学大学院理学系研究科
Research organization
  • (In Japanese)東京大学大学院理学系研究科
Report name (In Japanese)複合体形成に基づく膜タンパク質の機能制御
Technology summary (In Japanese)本研究は,本来短寿命である膜タンパク質の活性化状態に,これに強い親和性を示すことで脱感作を受けない天然毒などの外因性分子を用いて寿命を伸ばした状態での立体構造情報を取得解析し,これを静止状態での構造と比較することで膜タンパク質の活性化に関する構造的根拠を解明することを目的とする。特に,タンパク質の膜貫通部位に結合してこれを活性化すると想定されるシガトキシンなどの梯子状ポリ環状エーテル系海産毒をプローブ分子として,これらが結合する膜タンパク質との複合体に関する構造解析を目的に,次の研究を実施した。
Research field
  • NMR of organic compounds
  • Natural substances of biological origin
  • Molecular structure
  • Biomembrane in general
  • Toxicity of microorganism derived substances
Published papers related (In Japanese)(1)Masayuki Inoue, Makoto Sasaki and Kazuo Tachibana “A Convergent Synthesis of the trans-Fused Hexahydrooxonine Ring System and Reproduction of Conformational Behavior Shown by Ring F of Ciguatoxin” Tetrahedron, 55: (36) 10949-10970 (1999).
(2)Makoto Sasaki, Masayuki Inoue, Kuniyuki Takamatsu and Kazuo Tachibana “Stereocontrolled Synthesis of the JKLM Ring Fragment of Ciguatoxin” The Journal of Organic Chemistry, 64: (26) 9399-9415 (1999).
(3)Masayuki Inoue, Makoto Sasaki, and Kazuo Tachibana “A Convergent Synthesis of Decacyclic Ciguatoxin Model Containing the F-M Ring Framework” The Journal of Organic Chemistry, 64: (26) 9416-9429 (1999).
(4)Makoto Sasaki, Haruhiko Fuwa, Makoto Ishikawa, and Kazuo Tachibana “A General Method for Convergent Synthesis of Polycyclic Ethers Based on Suzuki Cross-Coupling; Concise Synthesis of the ABCD Ring System of Ciguatoxin” Organic Letters, 1: (7) 1075-1077 (1999).
(5)Keiichi Konoki, Masaki Hashimoto, Michio Murata, and Kazuo Tachibana “Maitotoxin-induced Calcium Influx in Erythrocyte Ghosts and Rat Glioma C6 Cells, and Blockade by Gangliosides and Other Membrane Lipids. “Chemical Research in Toxicology, 12: (10) 12993-1001 (1999).
(6)Makoto Sasaki, Katsuhiko Noguchi, Haruhiko Fuwa, and Kazuo Tachibana “Convergent Synthesis of an HIJK Ring Model of Ciguatoxin via Suzuki Cross-coupling Reaction” Tetrahedron Letters, 41: (9) 1425-1428 (2000).
(7)Yoshimasa Kobayashi and Kazuo Tachibana “NMR Observation on Transbilayer Distribution of N-[13C]methylated Chlorpromazine in Asymmetric Lipid Bilayer of Unilammellar Vesicles” Chemistry Letters, 4 302-303 (2000).
Research project
  • Core Research for Evolutional Science and Technology;Creation and Functions of New Molecules and Molecular Assemblies
Information research report
  • (In Japanese)橘 和夫. 電子・光子等の機能制御 複合体形成に基づく膜タンパク質の機能制御. 戦略的基礎研究推進事業 平成11年度 研究年報.科学技術振興事業団, 2000. p.689 - 693.