TOP > 研究報告検索 > 活性酸素による脳・神経細胞の障害とその防御機構


研究報告コード R000000284
掲載日 2002年9月30日
  • 中別府 雄作
  • 九州大学生体防御医学研究所
  • 九州大学生体防御医学研究所
報告名称 活性酸素による脳・神経細胞の障害とその防御機構
報告概要 我々は,ヒトの脳・神経系における活性酸素による細胞障害に対する防御系として,

※ 画像をクリックすると拡大します。

R000000284_01SUM.gif R000000284_02SUM.gif
  • 生物学的機能
  • 細胞構成体の機能
  • 中枢神経系
  • 神経の基礎医学
関連発表論文 (1)Nishioka, K., Ohtsubo, T., Oda, H., Fujiwara, T., Kang, D., Sugimachi, K., and Nakabeppu, Y. (1999). Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGGl mRNAs. Mol. Biol. Cell. 10,(5),1637-1652.
(2)Fujikawa, K., Kamiya, H., Yakushiji, H., Fujii, Y., Nakabeppu, Y., and Kasai, H. (1999). The oxidized forms of dATP are substrates for the human MutT homologue, the hMTHl protein. J. Biol. Chem. 274(26), 18201-18205.
(3)Ito, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., and Yamamoto, K. (1999). JSAPl, a novel JNK-binding protein that functions as a sacffold factor in the JNK signaling pathway. Mol. Cell. Biol.19,(11)7539-7548.
(4)Oda, H., Taketomi, A, Maruyama, I., Itoh, R., Nishioka, K., Yakushiji, H., Suzuki, T., Sekiguchi, M., and Nakabeppu, Y., (1999). Multi-forms of Human MTHl Polypeptides Produced by Alternative Translation Initiation and Single Nucleotide Polymorphism. Nucleic Acid Res. 27, (22), 4335-4343.
(5)Fujii, Y., Shimokawa, H., Sekiguchi, M., and Nakabeppu, Y. (1999). Functional significance of the conserved residues for the 23 residue module among MTHl and MutT family proteins. J. Biol. Chem., 274(53),38251-38259.
(6)Shimura-Miura,H., Hattori, N., Kang, D., Miyako, K., Nakabeppu, Y. and Mizuno, Y. (1999). Increased 8-oxo-dGTPase in the Mitochondria of Substantia Nigral Neurons in Parkinson's Disease. Ann. Neurol., 46(6), 920-924.
(7)Kalinichev, M., Rosenblatt, J.S., Nakabeppu, Y., and Morrell, J. (2000). Induction of c- Fos- and FosB-like immunoreactivity reveals forebrain neuronal populations differentially involved in pup-mediated maternal behavior in juvenile and adult rats. Journal of Comparative Neurology, 416(1),45-78.
(8)Ohyagi, Y., Yamada, T., Nishioka, K., Clarke, N. J., Tomlinson, A. J., Naylor, S., Nakabeppu, Y., Kira, J. Younkin S. G. (2000). Selective increase in cellular A?42 is related to apoptosis but not necrosis. NeuroReport, 11(1), 167-171.
(9)Kawate, H., Itoh, R., Sakumi, K., Nakabeppu, Y., Tsuzuki, T., Ide, F., Ishikawa, T., Noda, T., Nawata, H., Sekiguchi, M. (2000). A defect in a single alelle of the Mlh1 gene causes dissociation of killing and tumorgenic actions of an alkylating carcinogen in methyltransferase-deficient mice. Carcinogenesis, 21(2), 301-305.
(10)Inoue, R., Abe, M., Nakabeppu, Y., Sekiguchi, M., Mori, T., and Suzuki, T. (2000). Characterization of Human Polymorphic DNA Repair Methyltransferase. Pharmacogenetics, 10, 59-66.
(11)Ohtsubo, T., Nishioka, K., Imaiso, Y., Iwai, S., Shimokawa, H., Oda, H., Fujiwara, T, and Nakabeppu, Y. (2000). Identification of human MutY homolog(hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multi-forms of hMYH located in nuclei and mitochondria. Nucleic Acids Res., 28(6), 1355-1364
(12)Morifuji, M., Taniguchi, S., Sakai H., Nakabeppu, Y., and Ohishi, M. (2000). Differential Expression of Cytokeratin in Newly Established Human Tongue Cancer Cell Lines of Defined Metastatic Ability with Orthotopic Implantation. Am. J. Pathol., 156(4), 1317-1326.
  • 戦略的基礎研究推進事業、研究領域「脳を守る」研究代表者 中別府 雄作(九州大学生体防御医学研究所)/科学技術振興事業団
  • 中別府 雄作. 脳を守る 活性酸素による脳・神経細胞の障害とその防御機構. 戦略的基礎研究推進事業 平成11年度 研究年報.科学技術振興事業団, 2000. p.944 - 952.